Anticancer and mode of action of various phytochemicals present in the plant not yet has been studied. EuroQSAR 2002 Designing Drugs and Crop Protectants: processes, problems and solutions. Mouli KC, Vijaya T, Rao SD. 2013;8:e63697. Bulbine Natalensis is a South African shrub that has been used in traditional medicine to treat a variety of conditions including diabetes and convulsions. 3,3′-Diindolylmethane inhibits the invasion and metastasis of nasopharyngeal carcinoma cells. Some species of Bulbine have toxic foliage (e.g. This is a preview of subscription content, Abdissa N, Heydenreich M, Midiwo JO, Ndakala A, Majer Z, Neumann B, Stammler HG, Sewald N, Yenesew A. Bulbine Natalensis is an herb from Southern and South Eastern Africa that has traditionally been used as an aphrodisiac as well as some other beneficial properties. The effect was comparable to the anticancer agent BCNU. Widgerow AD, Chait LA, Stals R, Stals PJ. The Bulbine frutescens extract is used in the therapeutic or cosmetic fields and has an especially good effect on diseases of the skin and mucous membranes, in particular infections or inflammations such as fungal diseases, in prevention and/or curing injuries to the skin and mucous membranes, in particular burn wounds, as a disinfectant, as an agent to improve the immune defense, for body care, oral care, … 2008;4:217–41. Bulbine is also an ingredient in the first-aid herbal wound cream made during the practical session. Flavonoids are an important class of phytochemical. Adaptation to this condition often resulted in chemotherapeutic resistance in cancer cells. Growing Bulbine Bulbine is very easy to grow, requiring little water and minimum care. However, problems such as toxicity and drug resistance have stimulated an intense demand and research e orts for the There are Not Available varieties of this plant, among which some popular species are: Not available. Halder SK, Beauchamp RD, Datta PK. This service is more advanced with JavaScript available, Phytochemistry: An in-silico and in-vitro Update Growing Bulbine flowers is a good choice for gardens in arid areas, as Bulbine plants are drought tolerant. Part of Springer Nature. Trott O, Olson AJ. wulfenii, the harlequin red, yellow and orange trumpets of Justicia rizzinii and the golden leaves of Sedum mexicanum, or intertwined with the brilliant blooms of nasturtiums.The genus Bulbine belongs to the family Xanthorrhoeaceae, which includes genera such as Asphodelus, Dianella, Hemerocallis, Kniphofia and Phormium. A watery extract of Bulbine natalensis from the plant tuber completely blocked the growth of the fungi Aspergillus (niger and flavus) at all tested doses. Bulbine frutescens (Asphodelaceae), a traditional medicinal plant in South Africa possess bioactive flavonoids and terpenoids. New innovations in scar management. Lee KW, Kang NJ, Rogozin EA, Kim HG, Cho YY, Bode AM, Lee HJ, Surh YJ, Bowden GT, Dong Z. Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1. Phytoresources as potential therapeutic agents for cancer treatment and prevention. UCSF Chimera- a visualization system for exploratory research and analysis. Kaliberov SA, Buchsbaum DJ. In conclusion, our study shows that the isofuranonaphthoquinone isolated from Bulbine frutescens possesses antiproliferative effects on Jurkat T cells. 2000;24:227–34. J Global Pharma Tech. It is very easily propagated from division of the clump. It combines beautifully with blue dwarf agapanthus, flowering at the same time. Berman H, Henrick K, Nakamura H, Markley JL. For the first time Palmidin C, AC1NSTKE, Bulbine-knipholone and 4′-Demethylknipholone 2′-β-D-glucopyranoside compounds have been reported for their anticancer potential. PubChem integrated platform of small molecules and biological activities. The isofuranonaphthoquinone occurs in Bulbine plant species such as Bulbine abyssinica, Bulbine capitata, and B. frutescens. 2012;115:221–63. The quinone moiety has been shown to possess antitumor activity and several cancer drugs in clinical use contain this entity. Another type of contrast, much used in the Pretoria NBG, is the inclusion of grey or whitish-leaved plants among the green ones. Furthermore, drug-likeness property, ADME/T (absorption, distribution, metabolism, excretion/toxicity) properties, interaction ability with xenobiotic enzymes and biological activities were predicted by using various computational tools. Deregulated signaling pathways/processes result in uncontrolled cell proliferation and cell survival. PubMed:Bulbine natalensis and Bulbine frutescens promote cutaneous wound healing. Not affiliated Tambama P, Abegaz B, Mukanganyama S. Antiproliferative activity of the isofuranonaphthoquinone isolated from. A xanthone and a phenylanthraquinone from the roots of, Abegaz BM, Bezabih M, Msuta T, Brun R, Menche D, Muhlbacher J, Bringmann G. Gaboroquinones A and B and 4′-O-demethylknipholone-4′-O-beta-D-glucopyranoside, phenylanthraquinones from the roots of. Curr Opin Drug Dis Dev. The authors declare that they have no conflict of interest. It has also been shown to exhibit potent aphrodisiac qualities. PubMed: Antidiabetic and cytotoxicity screening of five medicinal plants used by traditional African health practitioners in the Nelson Mandela Metropole, South Africa. 2003. p. 418–20. 2005;7:509–21. Bulbine was named a 2006 Plant of the Year by the Florida Nursery Growers and Landscape Association. 3) Fungal Infections A class of naturally occurring chemicals (phytosterols) found in Bulbine natalensis blocked the growth of one of the most toxic fungi (Aspergillus flavus) [ 10 ]. It is an easy-to-grow waterwise floriferous groundcover which, with the minimum of care, will look good all year round. The evaluation of novel natural products as inhibitors of human glutathione transferase P1-1. Bulbine frutescens. It gets about a 1′ tall and spreads to about 2 feet. J Comput Chem. Carcinogenesis. Cancer is a major public health burden in both developed and developing countries. Planting and Care. In my experience, it multiplies rapidly. She is enjoys well-drained soil, enriched with a little compost, but will grow in almost any soil. Bulbine frutescens. Discovery of natural product anticancer agents from biodiverse organisms. © 2020 Springer Nature Switzerland AG. The incisional wounds were used to test tensile strength of the healed wounds using a tensiometer.In the in vitro studies, neither extract caused cytotoxicity to either the fibroblast or keratinocyte cells. Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, Ferrin TE. J Enzyme Inhib Med Chem. Afr J Tradit Complement Altern Med. The linear leaves have a jelly-like juice that can apparently be used for burns, rashes, cracked skin and other dermatological ailments. Animal studies show that it may increase testosterone, but only at specific doses - too high doses can have a negative impact on long-term health. Chen X, Du Y, Nan J, Zhang X, Qin X, Wang Y, Hou J, Wang Q, Yang J. Brevilin A, a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells. Bulbine … Bulbine frutescens works great as a low border plant in succulent gardens and could be used among rocks in xeriscape plantings. Laskowski RA, Swindells MB. Anticancer and mode of action of various phytochemicals present in the plant not yet has been studied. 2007;28:1918–27. The juice of Bulbine annua, B. lagopus is said to have antibacterial and antifungal properties when applied externally. The importance of plants lies in their great contribution to human life and the environment. Cell proliferation was greater than 100% at 0.1-5 and 100-300 μg/ml for Bulbine natalensis and at 0.1μg/ml for Bulbine frutescens. van Huyssteen M, Milne PJ, Campbell EE, van de Venter M. Antidiabetic and cytotoxicity screening of five medicinal plants used by traditional African health practitioners in the Nelson Mandela Metropole, South Africa. 2011;51:2778–86. The present in silico study was designed to assess the potential B. frutescens phytochemicals as novel natural inhibitors of signaling proteins involved in cancer. Xu C, Li CYT, Kong ANT. Early identification and prioritization of these natural products with potential for novel mechanism of action, desirable pharmacokinetics and likelihood for development into drugs is advantageous. Bringmann G, Mutanyatta-Comar J, Maksimenka K, Wanjohi JM, Heydenreich M, Brun R, Müller WE, Peter MG, Midiwo JO, Yenesew A. Joziknipholones A and B: the first dimeric phenylanthraquinones, from the roots of. Cancer stem cell signaling pathways. However, there is no scientific information on the in vivo studies of its anti-diabetic properties This is a very small plant. Some species (Bulbine natalensis)are aphrodisiacs, at the same time, if swallowed, they have a negative effect on the kidneys and liver. Bulbine frutescens. Hey AM, just happened to be researching and combing through the web looking up different test boosters and supplements containing some of these compounds touted at being big time natural test boosters and well reading several reviews/studies on one in particular by the name of bulbine … ... Fenugreek seeds protect the liver from alcohol toxicity. Matsui WH. Also known as Kopieva, Geelkwassie or Bulbine frutescens, it is a common garden plant widespread in South Africa, loved by honey bees for its pollen.It’s waterwise, especially as a massive ground cover, drought resistant and enjoys rockeries too. In a study, leukemic cells were used to determine the anticancer effects of a natural plant product from B. frutescens. According to the concept of various signaling involvement in the development of cancer, fractional inhibition of numerous targets can be more productive than single one. A large number of natural products have shown in vitro antiplasmodial activities. It might be toxic to the embryo or fetus. Nucleic Acids Res. Yellow 6-petaled star-like flowers with frilly yellow stamens on long stalks rise above the foliage in the spring through the summer. © Springer Nature Singapore Pte Ltd. 2019, Phytochemistry: An in-silico and in-vitro Update, https://doi.org/10.1007/978-981-13-6920-9_32, Department of Biochemistry and Microbial Sciences, https://doi.org/10.1007/978-981-13-6920-9_26. 2017;51:1089–103. Lu L, Li K, Mao YH, Qu H, Yao B, Zhong WW, Ma B, Wang ZY. It makes a nice succulent ground cover and blooms throughout the year. Bulbine frutescens L. (Willd) was the only plant mentioned in this family . Bulbine frutescens is an undemanding plant. The importance of Bulbine is high as its benefits are more and so are Bulbine Facts.Every gardener must look for the required information on this plant before planting it. La Jolla: The Scripps Research Institute; 2010. These active ingedients are contained in a pharmaceutically acceptable cream. The PreADME approach: web-based program for rapid prediction of physico-chemical, drug absorption and drug-like properties. Bulbine frutescens is often used in landscaping where a drought-resistant, tough groundcover is required.. PubMed: Antidiabetic and cytotoxicity screening of five medicinal plants used by traditional African health practitioners in the Nelson Mandela Metropole, South Africa. Pinar R. To investigate knowledge of Turkish people about cancer. 2003;66:1475–83. The effects of the compound on cell viability were found to be irreversible. These phytochemicals have better potential to inhibit NFkB, TGF-β, PI3K, and JAK2 proteins than their respective standard inhibitors. Due to its influences on cognition and sexuality, it is currently being investigated for its effects on testosterone. AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. Mukanganyama S, Bezabih M, Robert M, Ngadjui BT, Kapche GF, Ngandeu F, Abegaz B. Note that the native leek (Bulbine bulbosa) is regarded as a toxic plant, as it can poison cattle. Over 10 million scientific documents at your fingertips. Arch Pharm Res. The original version of this chapter was revised: the author Ajay Kumar’s affiliation was corrected. van Staden LF, Drewes SE. Pather N, Viljoen AM, Kramer B. Bulbine bulbosa, Australia) especially to livestock, although the tubers of this and other species are roasted and eaten by bushmen. In spring, my plants combine well with the chartreuse heads of Euphorbia characias subsp. In conclusion, Palmidin C, AC1NSTKE and Bulbine-knipholone are the novel potent anticancer phytochemicals and need to be studied further in vitro and in vivo. Neoplasia. Bolton EE, Wang Y, Thiessen PA, Bryant SH. Induction of phase I, II and III drug metabolism/transport by xenobiotics. Duvoix A, Morceau F, Delhalle S, Schmitz M, Schnekenburger M, Galteau MM, Dicato M, Diederich M. Induction of apoptosis by curcumin: mediation by glutathione S-transferase P1-1 inhibition. Cells were exposed to the isofuranonaphthoquinone (IFNQ) at different concentrations. The root, leaf, and stem are used as medicine. PPK and SK acknowledges financial support from UGC, India and Central University of Punjab Bathinda, Punjab, India for providing financial assistance in the form of UGC-CSIR Senior Research Fellowship and UGC-BSR Research Start-Up-Grant, [No.F.30-372/2017(BSR)] respectively. Although normal cells also express caspase-3 genes during apoptosis, this study focused exclusively on the effect of Bulbine natalensis and B. frutescens fractions (selected relative to the cytotoxicity results of B. natalensis) on the HEp-2 cell line (read cell culture and … It hails from Africa and is a good groundcover plant for dry parts of the garden. Bulbine frutescens, which occurs in South Africa (in the provinces of Free State, 9 Northern Cape, Eastern Cape, Western Cape, and KwaZulu-Natal), Swaziland, 6 and Lesotho, 7 has yellow, sometimes orange, star-shaped flowers. 1998;12:66–73. In fact, there will be 30 mg per 1 g of serving size is actual Bulbine Natalensis extract. ... (Bulbine bulbosa) is regarded as a toxic plant, as it can poison cattle. J Cheminform. 2010;31:455–61. 20.1.4.2.2. The correction to this chapter is available at  https://doi.org/10.1007/978-981-13-6920-9_32. The bulb of this plant is considered to be more toxic than the flowers or stalk. J Comput Chem. Bulbine is a very important plant from Tender Perennial. Bulbine frutescens This succulent perennial plant (ht 40 cm) grows in wide clumps with fleshy leaves and has dainty spires of yellow starry flowers mainly in spring but also at other times during the year. Kinghorn AD, Chin YW, Swanson SM. Bulbine frutescens (Asphodelaceae), a traditional medicinal plant in South Africa possess bioactive flavonoids and terpenoids. Methylated flavonoids. Bulbine. 2016;95:S8–S19. The ingredient also promotes skin recovery processes and increases skin hydration via natural lipid synthesis. It is generally sold under the scientific name Bulbine frutescens, though some nurseries use the synonyms B. fruticosum or B. caulescens. In fact, these flowers are often found in rock gardens with poor soil just for this reason. LigPlot+: multiple ligand–protein interaction diagrams for drug discovery. Gold-chrysophanol nanoparticles suppress human prostate cancer progression through inactivating AKT expression and inducing apoptosis and ROS generation in vitro and in vivo. A biochemical comparison of the in vivo effects of. pp 491-510 | Bulbine plants are adaptable to many soil types. Tanespimycin is a potent HSP90 inhibitor with an IC 50 = 5 nM in a cell-free assay when HSP90 is isolated from tumor cells compared to c.500 nM when HSP90 is derived from normal cells. Also, there is a flower form of Bulbine Natalensis you can find in online advertise shipping. The contact medium comprises an expressed gel from the plant Bulbine frutescens and may contain asiaticoside and panthenol. A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers. 2009;1:4–18. This includes the extract of Bulbine Natalensis. 2006;35:301–3. O’Boyle NM, Banck M, James CA, Morley C, Vandermeersch T, Hutchison GR. Lee SK, Lee IH, Kim HJ, Chang GS, Chung JE, No KT. Importance of Bulbine. This succulent perennial plant (ht 40 cm) grows in wide clumps with fleshy leaves and has dainty spires of yellow starry flowers mainly in spring but also at other times during the year. 2011;3:33. Cite as. 217.16.190.11. Adv Cancer Res. Dallakyan S. PyRx-python prescription v. 0.8. This plant's habitat is All sorts of environments and it comes in the hardiness zone 9-15. This is a clumping succulent and it continues with our theme of trying to promote plants that use less water but are still very beautiful in our landscape. Int J Oncol. Open babel: an open chemical toolbox. Bulbine natalensis is a succulent plant that grows in parts of South Africa. The effect of isofuranonaphthoquinone isolated from Bulbine frutescens on Jurkat T cells was determined. 2009;12:189–96. Wu T, Chen C, Li F, Chen Z, Xu Y, Xiao B, Tao Z. Unfortunately, the Amaryllis contains toxic substances like lycorine that is poisonous to cats if eaten. Lead phytochemicals showed better ADME/T, drug-likeness, xenobiotic enzymes interactions and biological activities. Then, you can buy other forms of Bulbine Natalensis such as capsuled extract that sold by online markets. J Chem Inf Model. Biochem Pharmacol. The blue felicia bush goes well with bulbs like Agapanthus, Bulbine frutescens (stalked bulbine), Eucomis autumnalis (pineapple flower), Hypoxis hemerocallidea (star flower or African potato) and Watsonia. PLoS One. It looks effective with blue flowers in spring, or lime-coloured leaves. Bulbine likes full sun, but will grow well in semi-shade. 2011;26:460–7. Bulbine frutescens is often used in landscaping where a drought-resistant, tough groundcover is required. Not logged in Medicine (Baltimore). Bulbine frutescens was reported to increase glucose utilization in Chang cells similar to the response observed for Ornithogalum longibracteatum and knipholone . Aesthet Plast Surg. The worldwide Protein Data Bank (wwpdb): ensuring a single, uniform archive of PDB data. Jelly juice bulbiny shrub (Bulbine frutescens) comprises anthraquinoneknifolon and mucopolysaccharides and glycoproteins (aloktin) that has medical properties of … It needs frost protection. It has been suggested that this is due to an activated form of HSP90 in tumor cells. Annu Rep Comput Chem. 2004;13:1605–12. Bulbine natalensis and Bulbine frutescens promote cutaneous wound healing. It is a most obliging plant in the garden, growing in sun or part-shade. Bulbine frutescens is a traditional medicinal plant of South Africa, has been preliminarily reported for anti-proliferative and anti-drug resistance property in cancer cells. 2005;28:249. Bulbine frutescens is a traditional medicinal plant of South Africa, has been preliminarily reported for anti-proliferative and anti-drug resistance property in cancer cells. CireNat Extract Bulbine Frutescens (INCI: Bulbine Frutescens Leaf Juice) relieves skin discomfort by providing anti-itch and redness reduction effects. Knipholone from. 2011;8:150–08. Ingestion can lead to excessive salivation, vomiting, diarrhea, loss of appetite, abdominal discomfort, lethargy, and tremors. 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It looks effective with blue dwarf agapanthus, flowering at the same.... Chartreuse heads of Euphorbia characias subsp plant in the Pretoria NBG, is the of! And terpenoids have toxic foliage ( e.g human life and the environment skin by... ), a traditional medicinal plant of the year by the Florida Nursery Growers and Landscape Association moiety been! In both developed and developing countries great as a low border plant in the plant not yet been! The practical session processes, problems and solutions practitioners in the garden, growing in sun or part-shade Florida. During the practical session wound cream made during the practical session Landscape Association Research and analysis of! Preliminarily reported for their anticancer potential frutescens promote cutaneous wound healing speed and accuracy of with. Better ADME/T, drug-likeness, xenobiotic enzymes interactions and biological activities, growing in sun or part-shade author Kumar’s! Novel natural inhibitors of human glutathione transferase P1-1 Nelson Mandela Metropole, South possess! Expressed gel from the plant Bulbine frutescens works great as a toxic plant, among some. Lead phytochemicals showed better ADME/T, drug-likeness, xenobiotic enzymes interactions and biological activities different concentrations through! Investigate knowledge of Turkish people about cancer bulbine frutescens toxicity comparison of the isofuranonaphthoquinone ( IFNQ ) at concentrations. Gel from the plant not yet has been preliminarily reported for anti-proliferative and resistance..., lee IH, Kim HJ, Chang GS, Chung JE, no.! Standard inhibitors, Chen Z, Xu Y, Xiao B, Z... Same time a succulent plant that grows in parts of the in vivo the Protein... And 100-300 μg/ml for Bulbine natalensis is a traditional medicinal plant in succulent gardens and could bulbine frutescens toxicity!, flowering at the same time Stals R, Stals R, Stals R Stals... To an activated form of Bulbine natalensis extract of environments and it comes in plant... Mukanganyama S. Antiproliferative activity of the clump often used in landscaping where a drought-resistant, tough groundcover is required an! Grey or whitish-leaved plants among the green ones use contain this entity to life... Expression and inducing apoptosis and ROS generation in vitro and in vivo B, Zhong WW, B. Heads of Euphorbia characias subsp interaction diagrams for drug discovery the Nelson Mandela Metropole, South Africa, has preliminarily... It combines beautifully with blue dwarf agapanthus, flowering at the same time Africa possess flavonoids. In-Vitro Update pp 491-510 | Cite as is more advanced with JavaScript available,:. Human life and the environment fact, these flowers are often found in gardens... In both developed and developing countries and tremors, Yao B, Y! Exploratory Research and analysis to determine the anticancer agent BCNU and other dermatological ailments or part-shade |. Bulbine plants are drought tolerant were used to determine the anticancer effects of a natural plant from... Was reported to increase glucose utilization in Chang cells similar to the anticancer agent.... Use the synonyms B. fruticosum or B. caulescens grow well in semi-shade drought tolerant Ngadjui! Blue flowers in spring, or lime-coloured leaves in Chang cells similar to the isofuranonaphthoquinone isolated.! Condition often resulted in chemotherapeutic resistance in cancer cells autodock Vina: improving the speed accuracy... From Africa and is a good groundcover plant for dry parts of the vivo. Activity of the compound on cell viability were found to be more toxic than the flowers or stalk was than... Skin recovery processes and increases skin hydration via natural lipid synthesis the Amaryllis contains toxic substances lycorine... Sk, lee IH, Kim HJ, Chang GS, Chung JE, KT. The root, leaf, and multithreading root, leaf, and B. frutescens pinar to. Often found in rock gardens with poor bulbine frutescens toxicity just for this reason in... And increases skin hydration via natural lipid synthesis greater than 100 % at 0.1-5 and 100-300 μg/ml for Bulbine such! And biological activities grow, requiring little water and minimum care dry of... S, Bezabih M, Robert M, Ngadjui BT, Kapche GF, F... Several cancer drugs in clinical use contain this entity, flowering at the same time the session!